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HMOX1 — NFKB1

Pathways - manually collected, often from reviews:

• WikiPathways Oxidative Stress: NFKB1/SP1/NFE2L2 → HMOX1/GPX1/GPX3/NQO1/UGT1A6 (activation)
  

Text-mined interactions from Literome

Lavrovsky et al., Mech Ageing Dev 2000 : Age dependent increase of heme oxygenase-1 gene expression in the liver mediated by NFkappaB
Vicente et al., Br J Pharmacol 2001 : Our results suggest that inhibition of NF-kappaB binding could mediate the effects of ZM 230,487 on the modulation of HO-1 and iNOS protein expression
Hassoun et al., Surgery 2002 (Aortic Aneurysm, Abdominal...) : We examined the effects of regional intraischemic hypothermia on mesenteric I/R induced mucosal injury, NF-kappaB activation , and expression of iNOS and HO-1 ... Mesenteric I/R significantly increased intestinal permeability to ( 14 ) C inulin, histologic injury, activation of NF-kappaB , and iNOS and HO-1 expression when compared with sham control rats
Soares et al., J Immunol 2004 (MAP Kinase Signaling System) : In addition, HO-1 inhibited the activation of NF-kappaB , a transcription factor required for TNF-alpha mediated up-regulation of these genes in EC
Chen et al., J Cell Biochem 2004 (Carcinoma, Papillary...) : Furthermore, we demonstrated that increased levels of HO-1 and p21 expression are associated with an increase in the activity of NF-kappaB and that inhibiting NF-kappaB leads to a block in the induction of HO-1 and p21
Wijayanti et al., Antioxid Redox Signal 2004 (MAP Kinase Signaling System) : Role of NF-kappaB and p38 MAP kinase signaling pathways in the lipopolysaccharide dependent activation of heme oxygenase-1 gene expression
Dijkstra et al., J Pathol 2004 (Colonic Neoplasms...) : Oxidative stress prevented iNOS induction in an NF-kappaB dependent manner but increased HO-1 expression in CM-exposed DLD-1 cells
Wu et al., J Card Fail 2004 (Anoxia) : Furthermore, transfection assay using HO-1 promoter constructs revealed the involvement of the nuclear factor kB (NF-kB) and Activator protein-1 (AP-1) in the hypoxia induced activation of the HO-1 gene
Huang et al., Ann N Y Acad Sci 2005 : The level of HO-1 expression and its promoter activity mediated by resveratrol was attenuated by nuclear factor-kappa B (NF-kappaB) inhibitors, but not by mitogen activated protein kinase ( MAPK ) inhibitors
Laxmanan et al., J Am Soc Nephrol 2005 : By electrophoretic mobility shift assay, it was confirmed that CD40 signaling induced the transcriptional activation of HO-1 through the binding of NF-kappaB to its promoter
Pae et al., Atherosclerosis 2006 (Atherosclerosis) : Based on our findings, we suggest that Nrf2 dependent HO-1 expression induced by HA inhibits MCP-1 secretion, VCAM-1 expression and NF-kappaB activation associated with vascular injury and inflammation in atherosclerosis
Belcher et al., J Clin Invest 2006 (Anemia, Sickle Cell...) : Treatment of sickle mice with hemin further increases heme oxygenase-1 expression and inhibits hypoxia/reoxygenation induced stasis, leukocyte-endothelium interactions, and NF-kappaB , VCAM-1, and ICAM-1 expression
Tsai et al., Anesthesiology 2006 : The effects of HO-1 induction on nuclear factor E2-related factor 2 ( Nrf2 ) and nuclear factor kappaB (NF-kappaB) were also investigated
Kim et al., Lung Cancer 2008 (Lung Neoplasms) : Transfection studies with siRNA specific for Nrf2 and NF-kappaB revealed that HO-1 expression in A549 cells is mediated by transcriptional activation of Nrf2, but not NF-kappaB
Seldon et al., J Immunol 2007 (Inflammation) : HO-1 inhibits NF-kappaB ( i.e., RelA ) phosphorylation at Ser ( 276 ), a phosphoacceptor that is critical to sustain TNF-driven NF-kappaB activity in EC
Tranter et al., Free Radic Biol Med 2008 (Inflammation) : Furthermore, HO-1 and CO suppress NF-kappaB activation by IL-18
Hsieh et al., Toxicological sciences : an official journal of the Society of Toxicology 2008 : Statin induced heme oxygenase-1 increases NF-kappaB activation and oxygen radical production in cultured neuronal cells exposed to lipopolysaccharide ... Inhibition of the induced HO-1 by zinc protoporphyrin reduced the increased NF-kappaB activation and superoxides production ... This study revealed that simvastatin induced HO-1 led to increased NF-kappaB activation and superoxides production in the neuronal cells when exposed to LPS, and iron production may play a role in such a response
Zhao et al., Immunol Invest 2008 (Inflammation) : The cellular secretion of TNF-alpha, IL-1beta, IL-6, NO and IL-10 in supernatant, mRNA expression of TNF-alpha, COX-2, iNOS and HO-1 , protein expression of COX-2 and HO-1, and activation of NF-kappaB were assayed by ELISA, the Griess method, real-time quantitative PCR, and Western blot and immunocytochemistry method, respectively
Tsoyi et al., Cell Signal 2008 : LPS induced NF-kappaB and STAT-1 activation was partially prevented by HO-1 overexpression
Min et al., Int Immunopharmacol 2009 : Taken together, these results suggest that down-regulation of LPS induced NO production by 5-hydroxyzerumbone is mediated by the suppression of iNOS expression through the modulation of NF-kappaB activation and HO-1 induction in macrophage cells
Boost et al., Int J Mol Med 2009 : We, therefore, aimed to investigate the effects of the volatile anesthetics sevoflurane and isoflurane on NF-kappaB/IkappaBalpha dependent intracellular signal transduction in human monocytic THP-1 cells induced by tumor necrosis factor-alpha (TNF-alpha) and production of interleukin-8 (IL-8) and downstream heme oxygenase-1 (HO-1)
Rushworth et al., Cancer Res 2010 (Acute Disease...) : We show that inhibition of NF-kappaB increased HO-1 expression in primary AML cells compared with that of nonmalignant cells
Zhao et al., Zhongguo Ying Yong Sheng Li Xue Za Zhi 2006 (Shock, Septic) : The role of activated nuclear factor-kappa B(NF-kappaB) on the expression of heme oxygenase-1 induced by lipopolysaccharide (LPS) in rats ' myocardium was obversed, and the effect exerted in endotoxic shock was explored