◀ Back to EGF

EGF — JAK1

Pathways - manually collected, often from reviews:

• BioCarta egf signaling pathway: EGF/EGF-R complex (EGF-EGFR) → JAK1 (modification, activates)

Text-mined interactions from Literome

Akl et al., Planta Med 2012 (Breast Neoplasms...) : Western blot studies revealed that combined low-dose treatment of ?-tocotrienol and sesamin caused a marked reduction in EGF induced ErbB3 and ErbB4 receptors phosphorylation ( activation ) and a relatively large decrease in intracellular levels of total and/or phosphorylated c-Raf, MEK1/2, ERK1/2, PI3K, PDK1, Akt, p-NF?B, Jak1 , Jak2, and Stat1, as compared to cells treated with only one compound or in the vehicle treated control group
Leaman et al., Mol Cell Biol 1996 : Although JAK1 is phosphorylated in response to EGF , it is not required for STAT activation or for induction of the c-fos gene
Zou et al., J Biol Chem 1997 : EGF dependent phosphorylation of E12R2, JAK2 , Tyk2, and STAT3 was observed