Gene interactions and pathways from curated databases and text-mining

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BMP2 — JUNB

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: JUNB → BMP2 (increases, BMP2 Activity)
    Evidence: he DNA binding activities of c-Fos, FosB/Delta FosB, Fra-1, Fra-2, and JunB were up-regulated whereas JunD activity was decreased.

Text-mined interactions from Literome

Hollnagel et al., J Biol Chem 1999 : BMP2/4 rapidly induced transcript levels of the homeobox genes Msx-1 and Msx-2 and the proto-oncogene JunB , whereas c-jun transcripts displayed delayed albeit prolonged increase
Chalaux et al., J Biol Chem 1998 : BMP-2 induces transcriptional activation of JunB expression as early as 30 min after ligand addition, reaching maximal levels after 90 min. Increase of JunB mRNA correlates with a higher AP-1 binding activity