◀ Back to AKT1
AKT1 — SLC25A16
Text-mined interactions from Literome
Burrows et al., J Clin Endocrinol Metab 2011
(Carcinoma...) :
In vivo,
GDC-0941 reduced expression of HIF-1a,
phospho-AKT , GLUT-1, and lactate dehydrogenase A in FTC xenografts
Lin et al., Clin Cancer Res 2013
(Disease Models, Animal...) :
Targeting activated Akt with
GDC-0068 , a novel selective
Akt inhibitor that is efficacious in multiple tumor models ... We describe the preclinical pharmacology and antitumor activity of
GDC-0068 , a novel highly selective ATP-competitive
pan-Akt inhibitor currently in clinical trials for the treatment of human cancers ... The
effect of
GDC-0068 on
Akt signaling was characterized using specific biomarkers of the Akt pathway, and response to GDC-0068 was evaluated in human cancer cell lines and xenograft models with various genetic backgrounds, either as a single agent or in combination with chemotherapeutic agents ...
GDC-0068 blocked
Akt signaling both in cultured human cancer cell lines and in tumor xenograft models as evidenced by dose dependent decrease in phosphorylation of downstream targets