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AKT1 — SKP1
Text-mined interactions from Literome
Bao et al., Blood 1999
:
We found that erythropoietin (EPO) and
stem cell factor (SCF) activated
protein kinase B ( PKB/Akt ) in EPO dependent HCD57 erythroid cells
Blume-Jensen et al., Nat Genet 2000
:
The mutation completely disrupted PI 3'-kinase binding to Kit/SCF-R and reduced
SCF induced PI 3'-kinase dependent activation of
Akt by 90 %
Krystal et al., Clin Cancer Res 2000
(Carcinoma, Small Cell...) :
STI571 efficiently blocked
SCF mediated activation of mitogen activated protein kinase and
Akt , but did not affect insulin-like growth factor-1 or serum mediated mitogen activated protein kinase or Akt activation
Bayle et al., J Biol Chem 2004
:
SOCS6 reduced
SCF induced activation of ERK1/2 and p38 but not activation of
AKT or STATs in Ba/F3, murine embryonic fibroblast (MEF), or COS-7 cells
Möller et al., Blood 2005
:
SCF induced a rapid and transient phosphorylation of
Akt ( protein kinase B ) and FOXO3a
Khanzada et al., Oncogene 2006
(Carcinoma, Small Cell...) :
These responses correlated with the inhibition of
stem cell factor (SCF) stimulated activation of extracellular signal regulated kinase ( Erk ),
protein kinase B (PKB) and ribosomal S6 kinase by simvastatin
Dang et al., J Neurosci Res 2005
(Neurofibromatoses) :
Although the c-Kit ligand
stem cell factor (SCF) induces the phosphorylation of protein kinase B ( or
Akt ) and prevents apoptosis in Schwann cells, SCF has no effect on the proliferation or differentiation of Schwann cells
Zeuner et al., Cancer Res 2007
(Thrombocytopenia) :
In chemotherapy treated megakaryocytes,
SCF activated
Akt , neutralized the mitochondrial apoptotic machinery, and inhibited caspase activity
Suyama et al., Oncol Rep 2010
(Lung Neoplasms...) :
Using c-kit positive SCLC cells ( H209 and H69 cells ) and SCF as a model of the autocrine mechanisms, the
effects of
SCF , LY294002, PD98059 or STI571 on
Akt and Erk were assessed by Western blot analysis
Feuser et al., Mol Immunol 2011
:
The combined challenge of mast cells with IL-4,
SCF and Fc?RI cross linking substantially
up-regulated activation of
Akt , whereas blocking of Akt inhibited the pronounced production and release of IL-8 in response to the three mast cell agonists