Liu et al., Mol Immunol 2007
:
Further studies show that the triptolide mediated inhibitory effects of LPS induced activation of phosphatidylinositol-3 kinase (PI3-K)/Akt and nuclear NF-kappaB activation are involved in down-regulation of COX-2 and CCR7 expression resulting in impaired migration to secondary lymphoid organs of DC
Liu et al., Br J Oral Maxillofac Surg 2010
(Carcinoma, Squamous Cell...) :
Metastatic squamous cell carcinoma (SCC) of the head and neck expresses chemokine receptor 7 (CCR7) , which activates phosphoinositide-3 kinase (PI3K) to promote invasion and survival of SCC cells in the head and neck