Gene interactions and pathways from curated databases and text-mining

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CASP8 — CCL2

Text-mined interactions from Literome

Schaub et al., Circ Res 2003 : Caspase 8 (Csp8) activity increased in response to FasL/Chx treatment, and Csp8 inhibitors markedly reduced IL-1alpha release and MCP-1 upregulation
Masuda et al., Int Immunopharmacol 2009 (Bone Resorption) : While this agent induced caspase-8 activation, a caspase-8 inhibitor did not affect the decrease in MCP-1 production by alendronate and TLR ligands
Bian et al., Invest Ophthalmol Vis Sci 2011 : Caspase-5 knockdown reduced caspase-1 protein expression and activation and inhibited TNF-a induced IL-8 and MCP-1
Zhu et al., Muscle Nerve 2013 (Inflammation...) : Lack of caspase-3 decreased immobilization induced increased apoptotic myonuclei ( 3.2-fold ) and macrophage infiltration ( 2.2-fold ) in soleus muscle and attenuated increased monocyte chemoattractant protein-1 mRNA expression ( 2-fold in KO vs. 18-fold in WT ) in gastrocnemius