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RAC1 — TLR2
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Shen et al., Infect Immun 2010
(Listeriosis) :
Moreover, functional activation of PI3K and
Rac1 was
impaired in
TLR2 ( -/- ) and MyD88 ( -/- ) macrophages
West et al., Nature 2010
(Inflammation...) :
Both
TLR2 and MyD88 are
required for CEP induced stimulation of
Rac1 and endothelial migration
Wen et al., J Exp Med 2010
(Peritonitis...) :
Plexin-A4 is required for
TLR induced
activation of the small guanosine triphosphate hydrolase ( GTPase )
Rac1 ( ras related C3 botulinum toxin substrate 1 )
Jiang et al., PloS one 2012
(Uveitis) :
The synergistic
effect of
TLR2 and NOD2 ligands on
RAC activation might be explained by the observations that bacterial lipoprotein ( BLP, a TLR2 ligand ) was able to upregulate NOD2 expression and the combination of BLP and muramyldipeptide ( MDP, a NOD2 ligand ) enhanced the expression of RICK ( Rip2 ), the signaling molecule of NOD2