Gene interactions and pathways from curated databases and text-mining

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CASP12 — ENDOG

Text-mined interactions from Literome

Arnoult et al., EMBO J 2003 : Mitochondrial release of AIF and EndoG requires caspase activation downstream of Bax/Bak mediated permeabilization
Yang et al., Exp Mol Med 2006 : Modulation of Bax, Bcl-XL, and the Endo G proteins, release of mitochondrial cytochome c, and activation of caspase-3 and -9 all are involved in the CTX III triggered apoptotic process in human leukemia K562 cells
Bellyei et al., Apoptosis 2007 (Neoplasms) : Over expressing of Hsp16.2 protected cells against stress stimuli by inhibiting cytochrome c release from the mitochondria, nuclear translocation of AIF and endonuclease G , and caspase 3 activation
Kim et al., Int J Oncol 2010 (Adenocarcinoma...) : We also found that during OGD induced apoptosis the prosurvival protein kinase Akt is activated and inhibition of Akt by the phosphoinositide 3-kinase (PI3K) inhibitors LY294002 and wortmannin prevent OGD induced apoptosis, caspase-3 and -9 activation , and nuclear translocation of AIF and EndoG
Lee et al., Exp Gerontol 2010 : Furthermore, the expression of caspase 3 was enhanced in aged ileum with increased DNA fragmentation, while nuclear translocation of apoptosis inducing factor and endonuclease G were decreased with aging
Hsiao et al., Evidence-based complementary and alternative medicine : eCAM 2012 : Additionally, the apoptotic induction of bufalin on A375.S2 cells resulted from mitochondrial dysfunction related responses ( disruption of the d? ( m ) and releases of cytochrome c, AIF, and Endo G ), and activations of caspase-3 , caspase-8 and caspase-9 expressions