Klingelhoefer et al., J Rheumatol 1999
(Rheumatic Diseases) :
The dose dependent inhibiting effect on IL-2 and IFN-gamma expression was also detected with RT-PCR, while the amount of actin-specific mRNA transcript was not modified by IDS 23
Reed et al., Lymphokine Res 1986
:
At concentrations that produced 75-90 % suppression of proliferation in PHA stimulated PBMC cultures, IDS caused no decrease in interleukin 2 (IL2) production ( determined by bioassay ) or in IL2 receptor expression ( determined with anti-Tac antibody )