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ARF6 — FOXM1
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Gusarova et al., J Clin Invest 2007
(Carcinoma, Hepatocellular...) :
In this study, we used diethylnitrosamine/phenobarbital treatment to induce hepatocellular carcinomas (HCCs) in either WT mice or Arf ( -/- ) Rosa26-FoxM1b Tg mice, in which forkhead box M1b (FoxM1b) is overexpressed and
alternative reading frame ( ARF ) inhibition of
FoxM1 transcriptional activity is eliminated
Park et al., EMBO Mol Med 2011
(Carcinoma, Hepatocellular...) :
The observations indicate that FoxM1b is a potent activator of tumour metastasis and that the
Arf mediated inhibition of
FoxM1b is a critical mechanism for suppression of tumour metastasis