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APC — PCNA
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Yeung et al., Exp Cell Res 2000
:
The present study thus demonstrated the presence of the spindle checkpoint and
APC mediated
cyclin degradation in dinoflagellates
Shirayama et al., Nature 1999
:
Exit from mitosis in yeast involves accumulation of the cyclin kinase inhibitor Sic1 as well as
cyclin proteolysis
mediated by
APC/C bound by the activating subunit Cdh1/Hct1 ( APC ( Cdh1 ) )
Taieb et al., Curr Biol 2001
:
xFizzy accumulates to high levels in Meiosis I, and injection of antisense oligonucleotides to xFizzy blocks nearly all
APC mediated
cyclin B degradation and Cdc2/cyclin B ( MPF ) inactivation between Meiosis I and II
Grosskortenhaus et al., Dev Cell 2002
:
Rca1 inhibits
APC-Cdh1 ( Fzr ) and is
required to prevent
cyclin degradation in G2
Nixon et al., Curr Biol 2002
(Calcium Signaling) :
However,
APC/C dependent
cyclin degradation was elevated 6-fold when sperm raised cytosolic Ca ( 2+ ) levels above 600 nM
Song et al., Nat Cell Biol 2004
:
Although RASSF1A does not contribute to either the Mad2 dependent spindle assembly checkpoint or the function of Emi1 ( ref. 1 ), depletion of RASSF1A by RNA interference accelerated the mitotic
cyclin degradation and mitotic progression as a
result of premature
APC activation
Hall et al., Cell cycle (Georgetown, Tex.) 2004
:
At the end of G ( 1 ),
APC/C ( Cdh1 ) is
inhibited by
cyclin dependent kinase (CDK) phosphorylation of Cdh1
Yamamoto et al., Dev Biol 2005
(MAP Kinase Signaling System) :
Here, we show that the APC/C-Cdc20 can mediate cyclin B degradation in CSF arrested Xenopus eggs and extracts, in such a way that when Cdc2 activity is elevated beyond a critical level,
APC/C-Cdc20 dependent
cyclin B degradation is activated and Cdc2 activity consequently declines to the critical level ... Our results indicate that under CSF arrest, Mos/MAPK activity suppresses cyclin B degradation, preventing Cdc2 activity from falling below normal meta-II levels, whereas activation of
APC/C-Cdc20 mediated
cyclin B degradation at elevated levels of Cdc2 activity prevents Cdc2 activity from reaching excessively high levels
Lénárt et al., Curr Biol 2007
:
Our data also show that Plk1 is not required for prophase entry, but delays transition to prometaphase, and that Emi1 destruction in prometaphase is not essential for
APC/C mediated
cyclin A degradation
Nishiyama et al., Nature 2007
:
Our results also suggest that Erp1
inhibits cyclin B degradation by binding the
APC/C at its carboxy-terminal destruction box, and this binding is also enhanced by the Mos dependent phosphorylation
van Leuken et al., Biochim Biophys Acta 2008
(Neoplasms) :
An inactive
APC/C stabilizes Geminin,
Cyclin A and Cyclin B1, thereby securing completion of DNA synthesis and progression through G2-phase
Labit et al., EMBO J 2012
:
The activity of the
APC/C is positively
controlled by
cyclin dependent kinase (CDK) , but a second level of control must also exist because phosphorylation inactivates Cdc20, a mitotic APC/C co-activator
Caldon et al., Cell cycle (Georgetown, Tex.) 2013
(Genomic Instability...) :
In contrast,
cyclin E1 overexpression
led to inhibition of the
APC complex, prolonged metaphase and increased p107 association with CDK2
Lau et al., Cell Res 2013
:
Regulation of
APC ( Cdh1 ) E3 ligase activity by the
Fbw7/cyclin E signaling axis contributes to the tumor suppressor function of Fbw7
Pichler et al., EMBO J 1997
:
The
Anaphase Promoting Complex (APC) is
required for anaphase progression and B-type
cyclin proteolysis