Shiseki et al., Cancer Res 2003
(Colorectal Neoplasms) :
Both p29ING4 and p28ING5 activate the p21/waf1 promoter, and induce p21/WAF1 expression
Unoki et al., J Biol Chem 2006
(Neoplasms) :
We also found that ING4_v4 played dominant negative roles in the induction of p21 ( WAF1 ) promoter activation and in the suppression of cell motility by ING4_v1
Guo et al., J Biol Chem 2011
:
A citrulline mimicking Arg-NLS-Gln ING4 mutant, which has all Arg residues in the NLS mutated to Gln, loses its affinity for p53, can no longer promote p53 acetylation, and results in repression of downstream p21 expression