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FOS — MMP2
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Westermarck et al., FASEB J 1999
(Neoplasm Invasiveness...) :
This review will summarize the current view on the role of MMPs in tumor growth, invasion, and survival, and focus on the
role of mitogen activated protein kinases and
AP-1 and ETS transcription factors in the regulation of
MMP gene expression during invasion process
Kajanne et al., J Cell Physiol 2007
:
Here we provide genetic and biochemical evidence that EGF-R- and
AP-1 mediated signals are
required for
MMP expression and collagen contraction in fibroblasts
Oliver et al., J Rheumatol 2007
(Arthritis, Experimental...) :
We evaluated whether a vanadium
AP-1 inhibitor could
reduce MMP expression and subsequent joint damage in CIA
Hasegawa et al., Exp Cell Res 2009
(Neoplasm Invasiveness) :
To assess the role of AP-1 function, we examined the
effects of dominant negative
Fos ( DeltaFos ), BATF and siRNA against c-Jun on
MMP production in v-Crk transformed cells which have augmented production of MMP-2 and MMP-9
Zhang et al., J Surg Res 2009
:
AP-1 inhibits expression of
MMP-2/9 and its effects on rat smooth muscle cells
Liu et al., Clin Orthop Relat Res 2011
(Disease Models, Animal...) :
QUESTIONS/HYPOTHESIS : I hypothesize : ( 1 ) intracellular MMP-2 plays an important role during muscle atrophy by digesting intramuscular matrix ; ( 2 )
AP-1 and NFAT signal transduction pathways are
responsible for expression and activation of the intracellular
MMP-2 during muscle atrophy ; and ( 3 ) specific MMP-2 inhibitors can serve as a novel pharmacologic strategy in treating disuse induced muscle atrophy