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ILK — ILKAP
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
ILK
—
ILKAP
(direct interaction, two hybrid)
Leung-Hagesteijn et al., EMBO J 2001*
-
IRef Biogrid Interaction:
ILK
—
ILKAP
(physical association, affinity chromatography technology)
Leung-Hagesteijn et al., EMBO J 2001*
-
IRef Hprd Interaction:
ILK
—
ILKAP
(in vivo)
Leung-Hagesteijn et al., EMBO J 2001*
-
IRef Hprd Interaction:
ILK
—
ILKAP
(two hybrid)
Leung-Hagesteijn et al., EMBO J 2001*
-
IRef Intact Interaction:
ILK
—
ILKAP
(physical association, two hybrid)
Leung-Hagesteijn et al., EMBO J 2001*
-
IRef Intact Interaction:
ILK
—
ILKAP
(physical association, anti bait coimmunoprecipitation)
Leung-Hagesteijn et al., EMBO J 2001*
Text-mined interactions from Literome
Leung-Hagesteijn et al., EMBO J 2001
:
Condi tional expression of
ILKAP in HEK 293 cells resulted in selective inhibition of ECM- and growth factor
stimulated ILK1 activity, but did not inhibit Raf-1 kinase activity ... A catalytic mutant of
ILKAP , H154D, did not
inhibit ILK1 kinase activity ... Two cellular targets of ILK1, glycogen synthase kinase 3 beta ( GSK3beta ) and protein kinase B (PKB)/AKT, were differentially affected by
ILKAP mediated inhibition of
ILK1 ... Catalytically active, but not mutant ILKAP, strongly inhibited insulin-like growth factor-1 stimulated GSK3beta phosphorylation on Ser9, but did not affect phosphorylation of PKB on Ser473, suggesting that
ILKAP selectively
affects ILK mediated GSK3beta signalling ... We propose that
ILKAP regulates
ILK1 activity, targeting ILK1 signalling of Wnt pathway components via modulation of GSK3beta phosphorylation
Kumar et al., Oncogene 2004
(Cell Transformation, Neoplastic) :
ILKAP regulates
ILK signaling and inhibits anchorage independent growth ... In LNCaP prostate carcinoma cells, transient or stable expression of
ILKAP suppressed
ILK immune complex kinase activity, demonstrating an interaction between ILKAP and ILK ... Consistent with the silencing data,
ILKAP inhibition of
ILK selectively inhibited S9 phosphorylation of GSK3beta without affecting S473 phosphorylation of PKB
Tamura et al., Cancer Sci 2006
(Cell Transformation, Neoplastic) :
PP2Cdelta/ILKAP also forms a complex with ILK1 to
inhibit the GSK3beta mediated
integrin-ILK1 signaling in vivo, inhibiting cell cycle progression
Nakrieko et al., Cell cycle (Georgetown, Tex.) 2008
:
In addition, nuclear
ILK can be rapidly exported into the cytoplasm through a CRM1 dependent pathway, and its export is
enhanced by the type 2C protein phosphatase
ILKAP