UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

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HCFC1 — OGT

Pathways - manually collected, often from reviews:

Reactome Reaction: HCFC1 → OGT (direct_complex)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

IRef Biogrid Interaction: HCFC1 — OGT (direct interaction, enzymatic study) Capotosti et al., Cell 2011 *
IRef Biogrid Interaction: HCFC1 — OGT (physical association, affinity chromatography technology) Capotosti et al., Cell 2011 *
IRef Biogrid Interaction: HCFC1 — OGT (colocalization, biochemical) Havugimana et al., Cell 2012
IRef Biogrid Interaction: HCFC1 — OGT (physical association, affinity chromatography technology) Wysocka et al., Genes Dev 2003
IRef Biogrid Interaction: HCFC1 — OGT (physical association, affinity chromatography technology) Mazars et al., J Biol Chem 2010 *
IRef Biogrid Interaction: HCFC1 — OGT (physical association, affinity chromatography technology) Daou et al., Proc Natl Acad Sci U S A 2011 *
MIPS CORUM HCF-1 complex: HCF-1 complex complex (ASH2L-HCFC1-HDAC1-HDAC2-HSPA4-HSPA5-HSPA8-OGT-RBBP4-RBBP7-SAP30-SETD1A-SIN3A-SIN3B-SP1-SUDS3-WDR5-HSP90AA1-HSP90AB1) Wysocka et al., Genes Dev 2003
IRef Corum Interaction: Complex of 20 proteins (association, anti tag coimmunoprecipitation) Wysocka et al., Genes Dev 2003
IRef Hprd Interaction: HCFC1 — OGT (in vitro) Wysocka et al., Genes Dev 2003
IRef Intact Interaction: Complex of 15 proteins (physical association, tandem affinity purification) Hutchins et al., Science 2010
IRef Intact Interaction: Complex of 22 proteins (physical association, anti tag coimmunoprecipitation) Sowa et al., Cell 2009
IRef Intact Interaction: OGT — HCFC1 (physical association, anti bait coimmunoprecipitation) Capotosti et al., Cell 2011 *
IRef Intact Interaction: OGT — HCFC1 (physical association, anti tag coimmunoprecipitation) Wysocka et al., Genes Dev 2003
IRef Intact Interaction: OGT — HCFC1 (protein cleavage, protease assay) Capotosti et al., Cell 2011 *
IRef Intact Interaction: Complex of ACTB-PPP1CC-OGT-KMT2E-HCFC1-PPP1CA-STK38-PPP1CB (association, anti tag coimmunoprecipitation) Fujiki et al., Nature 2009
IRef Intact Interaction: Complex of 14 proteins (association, anti tag coimmunoprecipitation) Wysocka et al., Genes Dev 2003