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MTX1 — PTGS2

Text-mined interactions from Literome

Mello et al., Rheumatology (Oxford) 2000 (Arthritis, Rheumatoid) : To investigate the regulation of whole-blood cyclooxygenase-1 and -2 ( COX-2 and COX-1 ) activities by methotrexate (MTX) in rheumatoid arthritis ( RA ) patients
Vincent et al., Del Med J 2002 (Arthritis, Rheumatoid...) : We hypothesize that decreased renal elimination of MTX induced by the COX-2 inhibitor resulted in enhanced hematopoietic toxicity and immunosuppression causing the EBV associated lymphoproliferative disease
Vergne et al., J Rheumatol 1998 (Arthritis, Rheumatoid) : COX-1 and IL-1beta induced COX-2 mRNA expression were not inhibited by MTX