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CCNG1 — EPHB2
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O'Reilly et al., J Immunol 2009
:
These results show that during mitogenic stimulation of T and B lymphocytes
MEK/ERK signaling is
critical for two distinct processes, cell survival, mediated ( at least in part ) through phosphorylation and consequent inhibition of Bim, and cell
cycling , which proceeds independently of Bim inactivation
Wang et al., Blood 2013
(Leukemia, Myelomonocytic, Chronic) :
The aberrant Nras ( G12D/+ ) HSC function is associated with hyperactivation of ERK1/2 in HSCs. Conversely, downregulation of
MEK/ERK by pharmacologic and genetic approaches
attenuates the
cycling of Nras ( G12D/+ ) HSCs and prevents the expansion of Nras ( G12D/+ ) HSCs and myeloid progenitors