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PTPN11 — TYR

Text-mined interactions from Literome

Itoh et al., J Allergy Clin Immunol 1999 : Adding back each tyrosine to Fall revealed that ( 1 ) Tyr577 was necessary and sufficient for Shc phosphorylation ; ( 2 ) Tyr577 , Tyr612, and Tyr695 were involved in activation of SHP-2 , the Raf/ERK cascade, and c-fos transcription ; and ( 3 ) all tyrosines, but particularly Tyr612, Tyr695, Tyr750, and Tyr806, facilitated STAT5 activation
Banks et al., J Biol Chem 2000 : By using this system, we confirm that two tyrosine residues in the intracellular domain of murine LRb become phosphorylated to mediate LRb signaling ; Tyr ( 985 ) controls the tyrosine phosphorylation of SHP-2 , and Tyr ( 1138 ) controls STAT3 activation
Cunnick et al., J Biol Chem 2001 : We found that both Tyr-627 and Tyr-659 of Gab1 were required for SHP2 binding to Gab1 and for ERK2 activation by EGF
Howie et al., Blood 2002 : SAP blocking of the tyrosine phosphatase SHP-2 occurs primarily on Tyr281 of CD150 because SHP-2 requires both Tyr281 and Tyr327 for binding to CD150, and SAP binds to nonphosphorylated Tyr281
Ekman et al., Oncogene 2002 : SHP-2 is involved in heterodimer specific loss of phosphorylation of Tyr771 in the PDGF beta-receptor ... We could show that the loss of phosphorylation of Tyr771 was dependent on presence of intact binding sites for the protein tyrosine phosphatase SHP-2 on the PDGF beta-receptor
Bordin et al., Blood 2002 : In this study, we show that Tyr phosphorylation of band 3, elicited by pervanadate, N-ethylmaleimide, or diamide, greatly increases band-3 interaction with the tyrosine phosphatase SHP-2 in parallel with the translocation of SHP-2 to erythrocyte membranes
Hers et al., Biochem J 2002 : Inhibition of PI 3-kinase enhanced the insulin stimulated phosphorylation of IRS-1 on (i) Tyr ( 612 ) and Tyr ( 941 ) ( p85 binding sites ), concomitant with an increased association of the p85 subunit of PI 3-kinase ; ( ii ) Tyr ( 896 ) ( a Grb2 binding site ) ; and ( iii ) Tyr ( 1229 ) ( an SHP-2 binding site ), although little or no binding of SHP-2 to IRS-1 was detectable under any conditions
Yu et al., J Biol Chem 2006 : Tyr ( 567 ), an SFK binding site in Kit, and SFK activity were required for Gab2 tyrosyl phosphorylation and association with Shp-2
Meng et al., Journal of molecular cell biology 2010 (MAP Kinase Signaling System) : Furthermore, Tyr251 and Tyr301 of IL-22R1 are required for Shp2 binding to the IL-22R1