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FOXO1 — KLF2
Text-mined interactions from Literome
Kerdiles et al., Nat Immunol 2009
:
In naive T cells,
Foxo1 controlled the expression of the adhesion molecule L-selectin, the chemokine receptor CCR7 and the transcription factor
Klf2 , and its deletion was sufficient to alter lymphocyte trafficking ... Finally, growth factor withdrawal induced a
Foxo1 dependent increase in Sell,
Klf2 and Il7r expression
Lee et al., Cardiovasc Res 2013
(Diabetes Mellitus, Type 2...) :
This study was designed to evaluate the reciprocal
regulation of
KLF2 by the forkhead transcription factor
FOXO1 , and the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor atorvastatin, in hyperglycaemic conditions ... Adenoviral transfection of constitutively active
FOXO1 suppressed
KLF2 expression ... High-glucose induced,
FOXO1 mediated
KLF2 suppression was reversed by atorvastatin, suggesting that intensive statin treatment could be a therapeutic option in diabetic vascular dysfunction ... High-glucose induced,
FOXO1 mediated
KLF2 suppression was reversed by atorvastatin, suggesting that intensive statin treatment could be a therapeutic option in diabetic vascular dysfunction