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CBX8 — RNF2

Pathways - manually collected, often from reviews:

• Reactome Reaction: CBX8 → RNF2 (direct_complex)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: CBX8 — RNF2 (physical association, affinity chromatography technology) Gao et al., Mol Cell 2012
• IRef Biogrid Interaction: CBX8 — RNF2 (physical association, affinity chromatography technology) Vandamme et al., Mol Cell Proteomics 2011
• IRef Biogrid Interaction: CBX8 — RNF2 (direct interaction, pull down) Vandamme et al., Mol Cell Proteomics 2011
• MIPS CORUM Polycomb repressive complex 1 (PRC1, hPRC-H): Polycomb repressive complex 1 (PRC1, hPRC-H) complex (BMI1-CBX2-CBX4-CBX8-HSPA1B-HSPA1A-PHC1-PHC2-PHC3-RING1-RNF2-SCMH1-SMARCA5) Levine et al., Mol Cell Biol 2002
• MIPS CORUM Polycomb repressive complex 1 (PRC1, hPRC-H): Polycomb repressive complex 1 (PRC1, hPRC-H) complex (BMI1-CBX2-CBX4-CBX8-HSPA1B-HSPA1A-PHC1-PHC2-PHC3-RING1-RNF2-SCMH1-SMARCA5-YY1) Levine et al., Mol Cell Biol 2002
• MIPS CORUM CEN complex: CEN complex complex (BMI1-WDR11-CBX3-CBX8-CENPA-CENPB-CENPC-CENPH-CENPI-CENPK-CENPL-CENPM-CENPO-COBLL1-CUL4A-DDB1-DHX38-FBL-HSPA5-HSPA8-KIAA1429-KIF23-CENPU-NUP93-RACGAP1-RING1-RNF2-RSF1-SHCBP1-SMARCA5-SRRT-SSRP1-SUPT16H-WTAP-ZC3H13-ZFP91) Obuse et al., Genes Cells 2004
• IRef Corum Interaction: Complex of 75 proteins (association, chromatin immunoprecipitation assay) Obuse et al., Genes Cells 2004
• IRef Corum Interaction: Complex of 13 proteins (association, affinity chromatography technology) Levine et al., Mol Cell Biol 2002
• IRef Corum Interaction: Complex of 14 proteins (association, affinity chromatography technology) Levine et al., Mol Cell Biol 2002
• IRef Dip Interaction: Complex of CBX7-RNF2-CBX8-BMI1 (anti bait coimmunoprecipitation) El Messaoudi-Aubert et al., Nature structural & molecular biology 2010
• IRef Dip Interaction: CBX8 — RNF2 (direct interaction, bimolecular fluorescence complementation) Vincenz et al., Proc Natl Acad Sci U S A 2008
• Gene Ontology Complexes ubiquitin ligase complex: ubiquitin ligase complex complex (WWP2-RNF11-UBE2D2-TSPAN17-HSPA1A-DYRK2-CBLL1-CBX8-GPR37-TOPORS-SUGT1-FBXL7-MIB2-FBXL12-FBXO25-FBXW4-ARIH1-TRAF7-BRCC3-UBE2E1-BRAP-UBR2-RNF20-UBE4A-DNAJA1-FBXL4-RING1-RNF144B-RNF8-RNF2-UBE2L3) Koegl et al., Cell 1999, Kitagawa et al., Mol Cell 1999, Moynihan et al., J Biol Chem 1999, Cenciarelli et al., Curr Biol 1999, Ilyin et al., Genomics 2000, Imai et al., Mol Cell 2002, Ng et al., Oncogene 2003, Dong et al., Mol Cell 2003, Matheny et al., Nature 2004, Bouwmeester et al., Nat Cell Biol 2004, Li et al., Oncogene 2004, Frame et al., J Cell Sci 2004, Rajendra et al., J Biol Chem 2004, Zhu et al., Mol Cell 2005, Li et al., J Biol Chem 2006, Mailand et al., Cell 2007, Huen et al., Cell 2007, Maddika et al., Nat Cell Biol 2009, Robinson et al., Mamm Genome 1995, Wood et al., Mol Cell Neurosci 1998
• Gene Ontology Complexes PcG protein complex: PcG protein complex complex (PCGF1-RYBP-PCGF2-YY1-PCGF6-PHC2-RING1-PCGF5-SCML2-CBX8-CBX7-CBX6-RNF2-CBX2) Gearhart et al., Mol Cell Biol 2006, Vandamme et al., Mol Cell Proteomics 2011, Kanno et al., EMBO J 1995
• IRef Intact Interaction: Complex of 21 proteins (association, anti tag coimmunoprecipitation) Levine et al., Mol Cell Biol 2002
• IRef Intact Interaction: Complex of RNF2-PHC2-CBX8-PCGF2 (association, anti bait coimmunoprecipitation) Maertens et al., PloS one 2009
• IRef Intact Interaction: Complex of PHC1-PCGF2-PHC3-CBX2-PHC2-CBX8-CBX4-RNF2-RING1 (association, tandem affinity purification) Maertens et al., PloS one 2009
• IRef Intact Interaction: Complex of 11 proteins (association, anti tag coimmunoprecipitation) Levine et al., Mol Cell Biol 2002
• IRef Intact Interaction: Complex of 14 proteins (association, tandem affinity purification) Maertens et al., EMBO J 2010
• IRef Intact Interaction: Complex of 62 proteins (association, tandem affinity purification) Vandamme et al., Mol Cell Proteomics 2011
• IRef Intact Interaction: Complex of 11 proteins (association, tandem affinity purification) Maertens et al., PloS one 2009
• IRef Intact Interaction: CBX8 — RNF2 (colocalization, imaging technique) Dietrich et al., EMBO J 2007
• IRef Intact Interaction: CBX8 — RNF2 (physical association, anti tag coimmunoprecipitation) Vandamme et al., Mol Cell Proteomics 2011
• IRef Intact Interaction: CBX8 — RNF2 (direct interaction, pull down) Vandamme et al., Mol Cell Proteomics 2011
• IRef Intact Interaction: Complex of 17 proteins (association, tandem affinity purification) Maertens et al., EMBO J 2010
• IRef Intact Interaction: Complex of CBX8-BMI1-PHC2-RNF2-PCGF2 (association, anti bait coimmunoprecipitation) Maertens et al., PloS one 2009