Mühlenbeck et al., J Biol Chem 2000
:
Interestingly, activation of c-Jun N-terminal kinase (JNK) was only observed in response to either cross linked sTRAIL or anti-TRAIL-R2-IgG even in cell lines where both receptors were capable of signaling apoptosis and NF-kappaB activation
Zou et al., Cancer Res 2004
(Carcinoma, Non-Small-Cell Lung...) :
c-Jun NH2-terminal kinase mediated up-regulation of death receptor 5 contributes to induction of apoptosis by the novel synthetic triterpenoid methyl-2-cyano-3,12-dioxooleana-1, 9-dien-28-oate in human lung cancer cells
Tazzari et al., Cancer Res 2008
(Leukemia, Myeloid, Acute) :
Up-regulation of TRAIL-R2 expression was dependent on a protein kinase Calpha/c-Jun-NH ( 2 ) -kinase 2/c-Jun signaling pathway activated by perifosine through reactive oxygen species production