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JUN — SMAD2

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: Complex of SMAD2-TGIF1 → JUN (increases, SMAD2/TGIF1 Activity) Pessah et al., Proc Natl Acad Sci U S A 2001*
  Evidence: c-Jun, which enhances the association of Smad2 with the nuclear transcriptional corepressor TG-interacting factor (TGIF), thereby interfering with the assembly of Smad2 and the coactivator p300 in response to TGF-beta signaling
• OpenBEL Selventa BEL large corpus: SMAD2 → JUN (decreases, JUN Activity, SMAD2 Activity) Pessah et al., Proc Natl Acad Sci U S A 2001*
  Evidence: c-Jun, which enhances the association of Smad2 with the nuclear transcriptional corepressor TG-interacting factor (TGIF), thereby interfering with the assembly of Smad2 and the coactivator p300 in response to TGF-beta signaling
• NCI Pathway Database Regulation of nuclear SMAD2/3 signaling: AP1 complex (FOS-JUN) → SMAD2-3/SMAD4/SP1 complex (SMAD2_SMAD3-SMAD4-SP1) (transcription, activates)
  Brodin et al., J Biol Chem 2000
  Evidence: mutant phenotype, reporter gene, physical interaction, other species

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: SMAD2 — JUN (physical association, affinity chromatography technology) Pessah et al., Proc Natl Acad Sci U S A 2001*
• Gene Ontology Complexes transcription factor complex: transcription factor complex complex (ATF7IP-GSC-GCM1-MAFB-NKX2-1-NKX2-5-RARG-KLF4-FOXF1-FOXF2-FOXE3-LDB1-ZFHX3-GATA6-SNAI3-FOXH1-KAT5-AHR-EYA3-NFATC2-CRX-MED27-HES6-SKI-XRCC6-ARNTL-SUB1-JUN-SOX17-SCX-DMBX1-TCF4-TCF7-PDLIM1-TFEB-LBX1-TRRAP-NAA16-EPAS1-MGA-PTF1A-HOXD12-MEF2B-TFDP3-TFDP1-HDAC2-YY1-SMAD9-CLOCK-ONECUT3-SMAD5-SMAD6-SMAD7-SMAD1-SMAD2-PRKDC-RCOR2-NHLH2-REL-TBX5-ARNTL2-BSX-HOXA10-HOXB13-MED23-PUS1-TAL1-RBL1-RBL2-MINA-HMGA1-BARX2-LEF1-EP300-PMF1-ARID5A-WWTR1-LMO2-LMO4-TP73-ABT1-CDK2-DKFZp686M216-CREG1-CTNNB1-SOX9-HAND2-SOX2-TEAD2-MYOG-TEAD4-CEBPA-GFI1B-MYOD1-ALX1-NPAS4-TFAP2D-FIGLA-ALX4-ETS1-PROP1-ASCL3-HCLS1-MSX1-MSX2-SRA1-AJUBA-MTA2-SIN3A-POU3F2-POU3F1-BEX1-MLXIPL-NR2E3-PBX2-ANKRD1-E2F6-E2F5-E2F4-E2F3-E2F2-E2F1-E2F8-CREBBP-ATF5-ATF4-POU2F3) Kaspar et al., J Biol Chem 1999, Wang et al., J Biol Chem 1999, Nagpal et al., J Biol Chem 1999, Blixt et al., Genes Dev 2000, Carlberg et al., Mol Cell Biol Res Commun 2000, Bae et al., Development 2000, Cairo et al., Hum Mol Genet 2001, Tutter et al., Genes Dev 2001, Willis et al., J Biol Chem 2002, Bayne et al., Mol Hum Reprod 2004, Schubert et al., J Biol Chem 2004, Han et al., J Mol Biol 2005, Rodriguez et al., EMBO J 2005, Han et al., Nucleic Acids Res 2005, Zhang et al., Mol Cell Biol 2007, Wong et al., Cell 2009, Stevens et al., Immunology 2009, Stefanovic et al., J Cell Biol 2009, Skokowa et al., Nat Med 2012, Ge et al., Cell 1994, Durocher et al., EMBO J 1997, Hogenesch et al., Proc Natl Acad Sci U S A 1998, Hellqvist et al., J Biol Chem 1998, Ryu et al., Nature 1999
• IRef Hprd Interaction: SMAD2 — JUN (in vivo) Liberati et al., Proc Natl Acad Sci U S A 1999, Pessah et al., Proc Natl Acad Sci U S A 2001*
• IRef Hprd Interaction: SMAD2 — JUN (in vitro) Liberati et al., Proc Natl Acad Sci U S A 1999, Pessah et al., Proc Natl Acad Sci U S A 2001*
• IRef Intact Interaction: SMAD2 — JUN (physical association, display technology) Miyamoto-Sato et al., PloS one 2010
• IRef Ophid Interaction: SMAD2 — JUN (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Pessah et al., Proc Natl Acad Sci U S A 2001 : c-Jun interacts with the corepressor TG-interacting factor (TGIF) to suppress Smad2 transcriptional activity ... Interestingly, c-Jun directly binds to the nuclear transcriptional corepressor TGIF and is required for TGIF mediated repression of Smad2 transcriptional activity
Sundqvist et al., Oncogene 2013 (Breast Neoplasms...) : Finally, chromatin immunoprecipitations showed that c-Jun , JunB and Fra1, but not c-Fos, are required for TGFß induced binding of Smad2/3 to the mmp-10 and pai-1 promoters