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IL8 — LEP

Text-mined interactions from Literome

Maruna et al., Vnitr Lek 2001 (Acute-Phase Reaction...) : Leptin mediates at least partly the anorectic effect of the tumour necrosis factor and interleukin 1 during inflammation
Bruun et al., Mol Cell Endocrinol 2002 : In contrast, IL-6 and IL-8 had no effect on either leptin production or leptin gene expression
Fukuda et al., Fertil Steril 2003 : The effects of leptin on the production of IL-6, IL-11, leukemia inhibitory factor (LIF), IL-8 , growth regulated oncogene ( GRO ) -alpha, monocyte chemoattractant protein (MCP)-1, and macrophage inflammatory protein (MIP)-3alpha by ESC and the endometrial epithelial cell line HHUA were investigated
Quinton et al., Am J Reprod Immunol 2003 : The effect of leptin on cell growth and on the production of cytokines [Leukaemia Inhibitory Factor (LIF), interleukin 6 and tumour necrosis factor-alpha ] and matrix metalloproteinases ( MMP ) ( MMP2 and MMP-9 ) was also investigated
Frisullo et al., J Clin Immunol 2004 (Multiple Sclerosis, Relapsing-Remitting) : Our data showed that leptin induced tumor necrosis factor-alpha, interleukin-6 , and interleukin-10 production by PBMCs of patients in an acute phase of disease but not in patients in a stable phase or in healthy controls
Tong et al., Cell Signal 2008 (Arthritis, Rheumatoid...) : Leptin induces IL-8 expression via leptin receptor, IRS-1, PI3K, Akt cascade and promotion of NF-kappaB/p300 binding in human synovial fibroblasts ... Leptin caused concentration- and time dependent increases in IL-8 production ... Leptin mediated IL-8 production was attenuated by OBRl receptor antisense oligonucleotide, JAK2 inhibitor or STAT3 small interference RNA ( siRNA ) ... These results suggest that leptin increased IL-8 production in synovial fibroblast via the OBRl/JAK2/STAT3 pathway, as well as the activation of IRS1/PI3K/Akt/NF-kappaB dependent pathway and the subsequent recruitment of p300
Kitahara et al., Biochem Biophys Res Commun 2009 (Arthritis, Rheumatoid) : Adiponectin, but not leptin or resistin induced interleukin-8 production from rheumatoid synovial fibroblasts ( RSF )
Vuolteenaho et al., Mediators Inflamm 2009 (Inflammation...) : Interestingly, inhibition of leptin induced NO production with a selective iNOS inhibitor 1400 W inhibited also the production of IL-6, IL-8, and PGE ( 2 ), and this was reversed by exogenously added NO-donor SNAP, suggesting that the effects of leptin on IL-6, IL-8 , and PGE ( 2 ) production are dependent on NO
Granowitz et al., Biochem Biophys Res Commun 1997 (Inflammation) : When considered in the context of animal studies showing that interleukin-1 and tumor necrosis factor-alpha induce leptin and ob mRNA, these results suggest that pro-inflammatory cytokines induce ob gene transcription in vivo via secondary mediators such as transforming growth factor-beta