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BMP2 — COMP
Text-mined interactions from Literome
Kipnes et al., Osteoarthritis Cartilage 2003
:
However, at later times in micromass culture, ectopic
COMP expression in the
presence of
BMP-2 causes an increase in apoptosis, with an accompanying reduction in cell numbers in the micromass culture
Tian et al., Beijing Da Xue Xue Bao 2003
:
[
Effects of
bone morphogenetic protein-2 on
cartilage oligomeric matrix protein expression in chondrocytes ] ... To quantitatively evaluate the
effects of
BMP-2 on the
COMP gene expression in both primary human chondrocytes and chondrogenic cell line ATDC55 ... We found that
BMP-2 up-regulated
COMP gene expression by approximate 3 folds in human adult chondrocytes, and 1.5 folds in human fetal chondrocytes ... For further analysis of the
effect of
BMP-2 on
COMP gene expression by RT-PCR, a rat chondrogenic cell line of ATDC55 cells was used
Ishida et al., Bone 2013
(Choristoma...) :
COMP binding enhanced BMP-2 induced intracellular signaling through Smad proteins,
increased the levels of
BMP receptors, and up-regulated the luciferase activity from a BMP-2-responsive reporter construct ... In summary, this study demonstrates that
COMP enhances the osteogenic activity of
BMP-2 , both in-vitro and in-vivo