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DKK3 — WNT16
Text-mined interactions from Literome
Holmen et al., Biochem Biophys Res Commun 2005
:
Dkk1, but not the related
Dkk3 , binds LRP6 and
inhibits canonical
Wnt signaling by blocking the interaction of Wnt and LRP6
Nakamura et al., BMC cell biology 2007
(Retinal Degeneration) :
We demonstrated that
Dkk3 potentiated
Wnt signaling in Müller glia and HEK293 cells but not in COS7 cells, indicating that it is a cell-type specific regulator of Wnt signaling
Ding et al., World J Gastroenterol 2009
(Carcinoma, Hepatocellular...) :
DKK-3 and WIF-1 acted as Wnt-antagonists and tumor suppressors, but hypermethylation of the gene promoter and low mRNA expression
activated Wnt signaling aberrantly and induced the development of HCC
Bao et al., Science signaling 2012
:
The structural basis of
DKK mediated inhibition of
Wnt/LRP signaling
Onai et al., Evol Dev 2012
(Wnt Signaling Pathway) :
The resemblance of the headless phenotype to that from upregulation of Wnt/ß-catenin signaling with BIO, a GSK3ß inhibitor, suggested that
Dkk3 might
inhibit Wnt/ß-catenin signaling ... We conclude that amphioxus
Dkk3 regulates head formation by modulating both
Wnt/ß-catenin and Nodal signaling, and that these functions may have been partitioned among various vertebrate lineages during evolution of Dkk3 proteins
Chang et al., PloS one 2012
:
DKK , an
inhibitor of
Wnt signaling, abolished Wnt3a induced effect but did not interfere GSK-3ß/14-3-3s binding
Zhu et al., Carcinogenesis 2012
(Neoplasm Invasiveness...) :
Furthermore, epigenetic modification of the
Dickkopf ( DKK ) family ( DKK1-DKK4 ) has been shown to be
important in
Wnt signaling regulation
Tamura et al., Clinical calcium 2013
(Wnt Signaling Pathway) :
Recently, numerous studies suggest that PTH enhances bone formation through the suppression of sclerostin,
DKK1 and sFRP1,
inhibitors of
Wnt-ß-catenin signal