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IRF8 — PTBP2

Text-mined interactions from Literome

Tamura et al., J Immunol 2005 : We found that IRF-4 is required for the generation of CD4 ( + ) DCs, whereas IRF-8 is, as reported previously, essential for CD8alpha ( + ) DCs
Tailor et al., Blood 2008 (Leukemia) : Together, this work indicates that IRF8-partner interactions play different roles in CD8alpha ( + ) DCs and pDCs, revealing a mechanistic separation that underlies development of these DC subsets
Tourkova et al., Cancer Immunol Immunother 2009 (Prostatic Neoplasms) : Thus, the aim of this work was to analyze the role of interferon regulatory factor 8 (IRF-8) in APM protein expression and the antigen presenting capacity of DCs developed in the tumor microenvironment ... Together, our data suggest that tumor induced inhibition of antigen processing and presenting function of DCs is mediated by IRF-8 , a member of the interferon regulatory factor family
Becker et al., Blood 2012 : Retroviral expression of IRF-8 in multiple progenitors led to reduced neutrophil production and increased numbers of DCs , even in the granulocyte-macrophage progenitor ( GMP ), which does not normally possess conventional DC potential
Seillet et al., Blood 2013 : We addressed the nature of the differentiation blocks observed in the absence of these factors and found that although all 4 factors are required for CD103+ DC development, only Irf8 is essential for CD8a+ DCs