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KAT2B — TP53

Pathways - manually collected, often from reviews:

• FastForward regulation: TP53 → KAT2B (transcriptional regulation, unknown) Wei et al., Cell 2006
  Evidence: DNABINDING
• NCI Pathway Database p53 pathway: PCAF (KAT2B) → p53 (tetramer) complex (TP53) (modification, activates)
  Le Cam et al., Cell 2006, Sakaguchi et al., Genes Dev 1998*, Liu et al., Mol Cell Biol 1999*
  Evidence: mutant phenotype, assay, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: KAT2B — TP53 (direct interaction, enzymatic study) Tang et al., Mol Cell 2006
• IRef Biogrid Interaction: KAT2B — TP53 (direct interaction, two hybrid) Zhao et al., Oncogene 2003*
• IRef Biogrid Interaction: KAT2B — TP53 (physical association, affinity chromatography technology) Perez et al., J Cell Physiol 2010*
• IRef Biogrid Interaction: KAT2B — TP53 (direct interaction, enzymatic study) Jin et al., J Biol Chem 2002*
• IRef Biogrid Interaction: KAT2B — TP53 (physical association, affinity chromatography technology) Wang et al., J Biol Chem 2008*
• IRef Biogrid Interaction: KAT2B — TP53 (physical association, affinity chromatography technology) Roe et al., Mol Cell 2006*
• IRef Biogrid Interaction: KAT2B — TP53 (physical association, affinity chromatography technology) Zhao et al., Mol Cell Biol 2006*
• IRef Hprd Interaction: TP53 — KAT2B (two hybrid) Sakaguchi et al., Genes Dev 1998*, Liu et al., Mol Cell Biol 1999*
• IRef Intact Interaction: Complex of TP53-KAT2B-TWIST1 (association, anti tag coimmunoprecipitation) Shiota et al., Oncogene 2008*
• IRef Intact Interaction: Complex of NFYA-KAT2B-TP53-HDAC1 (association, anti bait coimmunoprecipitation) Di Agostino et al., Cancer Cell 2006
• IRef Intact Interaction: Complex of KAT2B-TP53-NFYA-NFYA-KAT2B-TP53 (association, anti bait coimmunoprecipitation) Di Agostino et al., Cancer Cell 2006

Text-mined interactions from Literome

Nishimori et al., J Neurooncol 2000 (Astrocytoma...) : Since PCAF can regulate p53 activity, abrogation of PCAF function by PCAF gene mutation could be an alternate mechanism to inactivate the p53 pathway in tumors lacking p53 mutations
Jin et al., J Biol Chem 2002 : Because PCAF ( p300/CREB binding protein associated factor ) also acetylates and activates p53 after DNA damage, in this study we have examined the effect of MDM2 on PCAF mediated p53 acetylation ... Consistent with the above results, MDM2 significantly repressed the activation of p53 transcriptional activity by PCAF without apparently affecting the level of p53
Watts et al., Neoplasia (New York, N.Y.) 2004 (Breast Neoplasms) : Using microarrays, we discovered that PCAF itself is induced by p53 in a panel of breast tumor cell lines ... PCAF induction by p53 activity was further demonstrated in wild-type p53 MCF10A cells when PCAF expression was induced following activation of endogenous wild-type p53 with doxorubicin in a dose- and time dependent manner ... Taken together, the results show that PCAF expression can be induced by wild-type p53
Abida et al., J Biol Chem 2007 : This is consistent with recent studies showing that a lysine to arginine mutation at Lys-320 significantly enhances p53 function, although Lys-320 was originally identified as an acetylation site involving PCAF mediated activation of p53
Xenaki et al., Oncogene 2008 : In conclusion, PCAF regulates the balance between cell-cycle arrest and apoptosis in hypoxia by modulating the activity and protein stability of both p53 and HIF-1alpha
Love et al., Cell cycle (Georgetown, Tex.) 2012 : PCAF was required for the transcriptional activation of p21 in response to exogenous p53 in p53-null cells, nutlin-3, DNA damaging agents and p14(ARF) expression, suggesting a broad requirement for PCAF in p53 signaling to p21 after stress