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JAK3 — NOS2

Text-mined interactions from Literome

Sareila et al., Mediators Inflamm 2006 : We investigated the effects of Janus kinase ( JAK ) inhibitors, AG-490 and WHI-P154, on iNOS expression and NO production in J774 murine macrophages stimulated with interferon-gamma (IFN-gamma)
Choy et al., Proc Natl Acad Sci U S A 2007 : JAK signaling, initiated during T cell activation, inhibits iNOS expression
Sareila et al., Int Immunopharmacol 2008 : JAK3 inhibitors WHI-P154 ( 4- ( 3'-bromo-4'-hydroxylphenyl ) -amino-6,7-dimethoxyquinazoline ) and its derivative WHI-P131 inhibited LPS induced iNOS expression and NO production in a dose dependent manner
Wu et al., Br J Pharmacol 2009 : Effects of tripterine were investigated on endothelial barrier function, inducible nitric oxide synthase (iNOS) expression, nicotinamide adenine dinucleotide phasphate ( NADPH ) oxidase activity, 3-nitrotyrosine formation, protein phosphatase type 2A (PP2A) activity, activation of extracellular regulated kinase (ERK), c-Jun terminal kinase (JNK) and Janus kinase ( Jak2 ), and degradation of IkappaB in microvascular endothelial cells exposed to pro-inflammatory stimulus [ lipopolysaccharide (LPS) + interferon gamma (IFNgamma) ] and on vascular permeability in air pouches of mice injected with LPS + IFNgamma
Do et al., J Nutr Biochem 2010 (Brain Neoplasms...) : Suppression of iNOS expression by fucoidan is mediated by regulation of p38 MAPK, JAK/STAT , AP-1 and IRF-1, and depends on up-regulation of scavenger receptor B1 expression in TNF-alpha- and IFN-gamma stimulated C6 glioma cells