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LEP — MMP1
Text-mined interactions from Literome
Park et al., Exp Mol Med 2001
(Arteriosclerosis...) :
Leptin also induced
increases of MMP-2,
MMP-9 , TIMP-1, and Up-regulated the human coronary artery smooth muscle cells ( HCASMCs )
Quinton et al., Am J Reprod Immunol 2003
:
Expression of leptin receptor isoforms in vitro : lack of
effects of
leptin on endometrial cytokine and
MMP production ... The
effect of
leptin on cell growth and on the production of cytokines [Leukaemia Inhibitory Factor (LIF), interleukin 6 and tumour necrosis factor-alpha ] and
matrix metalloproteinases ( MMP ) ( MMP2 and MMP-9 ) was also investigated ...
Leptin had no effect on cytokine and
MMP production by these cells
Schulz et al., Biol Reprod 2004
:
Our results suggest that
leptin may play a role in the establishment of the placenta during early pregnancy and that this function is
dependent on
MMP activity
Choudhury et al., Metabolism 2006
:
Leptin ( 10-50 ng/mL )
had no significant effects on
MMP-1 or TIMP-1 mRNA levels, collagenolytic activity, or MMP-1 protein levels ... At these concentrations,
leptin does not
affect MMP-1 or TIMP-1 expression or collagenolytic activity of HSC
Cao et al., J Hepatol 2007
(Liver Cirrhosis...) :
Leptin represses
matrix metalloproteinase-1 gene expression in LX2 human hepatic stellate cells ... The
effect of
leptin on
MMP-1 production has not been reported ...
Leptin represses
MMP-1 gene expression via the synergistic actions of the JAK/STAT pathway and JAK mediated H2O2 dependent ERK1/2 and p38 pathways
Schram et al., J Mol Cell Cardiol 2008
:
Here we investigated the
effects of
leptin , circulating levels of which are typically increased in obese individuals, on
MMP and collagen expression and MMP activity in isolated cardiac myofibroblasts
Bao et al., Mol Biol Rep 2010
:
Leptin significantly
increased both gene and protein levels of MMP-2,
MMP-9 , cathepsin D, and collagen II, while decreased bFGF markedly in cartilage
Tao et al., Arterioscler Thromb Vasc Biol 2013
(Aortic Aneurysm, Abdominal...) :
Leptin and leptin receptor antigen were evident in all AAAs, and leptin,
MMP-9 , and MMP-12 mRNA was
increased relative to age matched nondilated controls