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PTGS2 — RAF1

Text-mined interactions from Literome

Wadleigh et al., J Biol Chem 2000 : In contrast, endotoxin induced COX-2 reporter activity is not blocked by overexpression of dominant negative forms of Raf-1 , ERK1, or ERK2
Teh et al., J Cell Biochem 2004 (Breast Neoplasms...) : bFGF regulation of survivin expression was found to be ERK1/2 kinase dependent and bFGF induced phosphorylation of c-raf was prevented by the COX-2 inhibitor
Chang et al., Cell Signal 2005 : PMA induced COX-2 expression was attenuated by PKC inhibitors ( Go 6976 and Ro 31-8220 ), a Ras inhibitor ( manumycin A ), a Raf-1 inhibitor ( GW 5074 ), a MEK inhibitor ( PD 098059 ), and an NF-kappaB inhibitor ( PDTC ), but not by a tyrosine kinase inhibitor ( genistein ) or a p38 MAPK inhibitor ( SB 203580 )
Gwak et al., J Cancer Res Clin Oncol 2006 : LPC induced Raf-1 activation was responsible for this COX-2 induction
Chang et al., Pharmacol Res 2009 : In this study, we further investigated the role of Raf-1 in YC-1 induced nuclear factor-kappaB (NF-kappaB) activation and COX-2 expression in A549 cells ... YC-1 induced COX-2 expression was attenuated by a Raf-1 inhibitor ( GW 5074 ) in a concentration dependent manner
Kim et al., Biochem Pharmacol 2010 : We conclude that MKK4, MEK1, and Raf-1 are targets of cyanidin for the suppression of UVB induced COX-2 expression