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ADCYAP1 — IL10

Text-mined interactions from Literome

Wang et al., Regul Pept 1999 : Previous reports indicate that VIP and the structurally related peptide PACAP , inhibit IL-2 and IL-10 production in antigen stimulated T lymphocytes ... The antagonists based on the neurotensin-VIP hybrid molecule did not affect the inhibitory effect of VIP/PACAP on IL-2 and IL-10 production, confirming that astrocytes and T lymphocytes express different receptors
Delgado et al., J Biol Chem 1999 : We showed previously that VIP and PACAP inhibit the production of macrophage derived tumor necrosis factor-alpha, interleukin (IL)-6 , nitric oxide, and IL-12
Leceta et al., Ann N Y Acad Sci 2000 (Inflammation) : VIP/PACAP inhibit the production of TNF alpha, IL-6, IL-12, and nitric oxide ( NO ), and stimulate IL-10 in peritoneal macrophages and Raw 264.7 cells ... VIP/PACAP inhibit iNOS expression through reduction in NFkB and IRF-1 binding, and augment IL-10 by increasing CREB binding
Kim et al., J Neuroimmunol 2002 : The inclusion of an anti-IL-10 antibody completely abrogated PACAP inhibition of lipopolysaccharide (LPS) induced CD40 expression, suggesting that PACAP inhibition is at least in part mediated by IL-10
Ganea et al., Crit Rev Oral Biol Med 2002 (Shock, Septic) : In activated macrophages, VIP and PACAP inhibit the production of pro-inflammatory agents ( cytokines, chemokines, and nitric oxide ), and stimulate the production of the anti-inflammatory cytokine IL-10
Zhang et al., Curr Eye Res 2005 : To examine pituitary adenylate cyclase activating polypeptide ( PACAP ) receptors ( PAC1, VPAC1, and VPAC2 ) mRNA and the effect of PACAP on interleukin-6 (IL-6), interleukin-8 (IL-8), and monocyte chemotactic protein-1 (MCP-1) expression in human retinal pigment epithelial cell line ( ARPE-19 ) stimulated with interleukin-1beta (IL-1beta)
Mester et al., J Mol Neurosci 2011 : PACAP receptors have been identified on the retinal pigment epithelial cells and PACAP has been shown to inhibit interleukin secretion from pigment epithelial cells
Temerozo et al., PloS one 2013 : VIP and PACAP up-regulated macrophage secretion of the ß-chemokines CCL3 and CCL5 and the cytokine IL-10 , whose neutralization reversed the neuropeptide induced inhibition of HIV-1 replication
Martinez et al., J Immunol 1996 : In this study, we investigated the effects of VIP and of the structurally related neuropeptide PACAP-38 on the expression of IL-10 in murine lymphocyte cultures ... The fact that VIP, PACAP-38 , and forskolin, all known cAMP inducers, also inhibit IL-10 production, suggests the participation of cAMP in signal transduction
Ganea et al., Adv Neuroimmunol 1996 : In contrast, the inhibitory effect of VIP and PACAP on IL-10 production proceeds through a direct transcriptional event
Jiang et al., Ann N Y Acad Sci 1998 : These results indicate that both subsets of peripheral T lymphocytes express VIP1 and VIP2, but not PVR1 receptors, and that the inhibitory effect of VIP/PACAP on IL-2 and IL-10 production is mediated by both VIP1 and VIP2 receptors
Delgado et al., J Immunol 1999 : Although VIP/PACAP do not induce IL-10 by themselves, they enhance IL-10 production in LPS stimulated macrophages