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JARID2 — RBBP7

Pathways - manually collected, often from reviews:

• Reactome Reaction: JARID2 → RBBP7 (reaction) Cao et al., Science 2002, Kuzmichev et al., Genes Dev 2002, Kuzmichev et al., Mol Cell 2004, Martin et al., J Biol Chem 2006, Margueron et al., Mol Cell 2008, McCabe et al., Proc Natl Acad Sci U S A 2012, Swalm et al., Biochem J 2013
• Reactome Reaction: JARID2 → RBBP7 (indirect_complex)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: Complex of 37 proteins Crockett et al., Proteomics 2005
• IRef Dip Interaction: JARID2 — RBBP7 (physical association, anti tag coimmunoprecipitation) Pasini et al., Nature 2010
• IRef Dip Interaction: Complex of 19 proteins (anti tag coimmunoprecipitation) Pasini et al., Nature 2010
• Gene Ontology Complexes ESC/E(Z) complex: ESC/E(Z) complex complex (SIRT1-HDAC2-JARID2-MTF2-RBBP7-PHF19-EZH2-H2AFY2-AEBP2-PHF1) Pasini et al., EMBO J 2004, Kuzmichev et al., Proc Natl Acad Sci U S A 2005, Buschbeck et al., Nature structural & molecular biology 2009, Pasini et al., Nature 2010, Ballaré et al., Nature structural & molecular biology 2012, Cai et al., Mol Cell 2013, Chu et al., Proc Natl Acad Sci U S A 2014

Text-mined interactions from Literome

Shen et al., Cell 2009 : In vitro JMJ inhibits PRC2 methyltransferase activity, consistent with increased H3K27me3 marks at PRC2 targets in Jmj ( -/- ) ESCs ... Paradoxically, JMJ is required for efficient binding of PRC2 , indicating that the interplay of PRC2 and JMJ fine-tunes deposition of the H3K27me3 mark
Pasini et al., Nature 2010 : JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells
Li et al., Genes Dev 2010 : Jarid2 can bind DNA and its recruitment in ES cells is interdependent with that of PRC2, as Jarid2 knockdown reduced PRC2 at its target promoters, and ES cells devoid of the PRC2 component EED are deficient in Jarid2 promoter access