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MIF — VEGFA
Text-mined interactions from Literome
Ren et al., Int J Cancer 2003
(Carcinoma, Hepatocellular...) :
MIF induced a significant dose dependent increase in IL-8 and
VEGF production
Ren et al., Oncogene 2004
(Neuroblastoma) :
In addition, we found that
MIF induced a significant dose dependent increase of
vascular endothelial growth factor and interleukin-8 secretion
Ren et al., Ann Surg 2005
(Carcinoma, Squamous Cell...) :
In addition, in vitro
MIF stimulation of esophageal cancer cell lines induced a dose dependent
increase in
VEGF and IL-8 secretion
Bondza et al., J Reprod Immunol 2008
(Adenocarcinoma...) :
Moreover, immunocytofluorescence revealed positive VEGF immunostaining compared to control, and analysis by ELISA of VEGF release in culture supernatants demonstrated that
MIF ( 25 ng/ml ) significantly
induced VEGF secretion at 12 and 24 h
Xu et al., Cancer Lett 2008
(Breast Neoplasms...) :
In addition, we investigated the expression of
MIF in MDA-MB-231, MCF-7 ( breast cancer cell lines ) and MCF-10A ( epithelial cell line ) cells, and its
effect on
VEGF and IL-8 ... Exogenous
MIF did not cause endothelial tube formation and migration but
induced a dose dependent increase in
VEGF and IL-8 secretion in breast cancer cell lines
Han et al., Clin Orthop Relat Res 2008
(Bone Neoplasms...) :
MIF expression correlated with microvessel density and
induced a dose dependent increase in
vascular endothelial growth factor
Coleman et al., J Immunol 2008
(Carcinoma, Non-Small-Cell Lung...) :
Because MIF has important autocrine effects on normal and transformed cells, we investigated whether autocrine
MIF and its only known family member, D-dopachrome tautomerase (D-DT),
promote the expression of proangiogenic factors CXCL8 and
vascular endothelial growth factor in NSCLC cells