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MCAM — VEGFA

Text-mined interactions from Literome

Chakraborty et al., J Biol Chem 2006 (Anoxia...) : Moreover, Syk and Lck play differential roles in regulating Sp1 activation and expressions of melanoma cell adhesion molecule (MelCAM) , urokinase-type plasminogen activator ( uPA ), matrix metalloproteinase-9 (MMP-9), and vascular endothelial growth factor ( VEGF ) in response to H/R. Overexpression of wild type Syk inhibited the H/R induced uPA, MMP-9, and VEGF expression but up-regulated MelCAM expression
Zhuang et al., Free Radic Biol Med 2010 : Here, we show that CD146 dimerization is induced by VEGF and is significantly diminished by pretreatment with diphenylene iodonium, an inhibitor of NADPH oxidase, suggesting a potential role for NADPH oxidase ( NOX ) in VEGF induced CD146 dimerization ... Importantly, we found that overexpression of NADPH oxidase 4 (NOX4), which is the predominant NOX expressed in endothelial cells, significantly enhances VEGF induced ROS generation and CD146 dimerization ... Furthermore, expression of Rac1 N17, a dominant negative mutant of Rac1, a member of the Rho family of small GTPases, suppressed VEGF induced ROS generation and CD146 dimerization