Gene interactions and pathways from curated databases and text-mining

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IFNG — TNFSF11

Text-mined interactions from Literome

Kotake et al., Eur J Immunol 2005 (Arthritis, Rheumatoid...) : Contrary to our hypothesis, IFN-gamma ( + ) human T cells induced osteoclastogenesis through the expression of RANKL , suggesting that Th1 cells play a direct role in bone resorption in Th1 dominant diseases such as RA
Park et al., Exp Mol Med 2005 : In addition, RANKL increased the expression of TNFalpha, MCP-1, and IL-6 but not of IL-10, IL-12, IFN-gamma , and iNOS
Tunyogi-Csapo et al., Arthritis Rheum 2008 (Arthritis, Rheumatoid...) : IL-4 suppressed RANKL expression and increased OPG expression, IFNgamma reduced the production of both RANKL and OPG, and IL-17 had only a modest effect on the expression of RANKL or OPG