◀ Back to IFNG
IFNG — TNFSF11
Text-mined interactions from Literome
Kotake et al., Eur J Immunol 2005
(Arthritis, Rheumatoid...) :
Contrary to our hypothesis,
IFN-gamma ( + ) human T cells
induced osteoclastogenesis through the expression of
RANKL , suggesting that Th1 cells play a direct role in bone resorption in Th1 dominant diseases such as RA
Park et al., Exp Mol Med 2005
:
In addition,
RANKL increased the expression of TNFalpha, MCP-1, and IL-6 but not of IL-10, IL-12,
IFN-gamma , and iNOS
Tunyogi-Csapo et al., Arthritis Rheum 2008
(Arthritis, Rheumatoid...) :
IL-4 suppressed RANKL expression and increased OPG expression,
IFNgamma reduced the production of both
RANKL and OPG, and IL-17 had only a modest effect on the expression of RANKL or OPG