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POT1 — RAC1
Text-mined interactions from Literome
Maillet et al., Nat Cell Biol 2003
(Alzheimer Disease) :
We also show that
Rac activation
results from activation of
Rap1 through the cAMP guanine nucleotide-exchange factor (GEF) Epac1
Arthur et al., J Cell Biol 2004
:
Rap1a activates
Rac1 and requires Rac1 to enhance spreading, whereas Rac1 induces spreading independently of Rap1
Sato et al., Cancer Sci 2005
:
The activation of Cdc42 and
Rac by the trans-interaction of nectin and nectin is
mediated by c-Src, another small G protein,
Rap1 , a Cdc42-GEF, FRG, and a Rac-GEF, Vav2 ... The trans-interaction of Necl-5 and nectin-3 also activates
Rap1 through C3G, a Rap-GEF, and this activation of Rap1 is
required for the activation of Cdc42 and
Rac
Birukova et al., Exp Cell Res 2007
(Respiratory Distress Syndrome, Adult) :
Prostaglandins PGE ( 2 ) and PGI ( 2 ) promote endothelial barrier enhancement via PKA- and
Epac1/Rap1 dependent
Rac activation
Guidetti et al., Journal of thrombosis and haemostasis : JTH 2009
:
However, when phosphorylation of PLCgamma2 was blocked by the Src kinase inhibitor PP2, prevention of
Rac1 activation significantly
reduced PLCgamma2 activation,
GTP-Rap1b accumulation, and alpha ( IIb ) beta3 stimulation
Malchinkhuu et al., Mol Biol Cell 2009
(Glioma) :
The expression of tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 ( PTEN ) is required for the inhibitory ISO induced and
Rap1B mediated
actions on the migration,
Rac1 activation, and Akt activation in response to LPA ... Thus, the PTEN mediated down-regulation of phosphatidylinositol 3-kinase activity may be involved in the regulation of
Rap1B dependent inhibition of
Rac1 activity
Stefanini et al., Arterioscler Thromb Vasc Biol 2012
:
Whereas
Rap1 signaling directly
controls sustained
Rac1 activation, Rac1 affects CalDAG-GEFI- and P2Y12 dependent Rap1 activation via its role in calcium mobilization and granule/ADP release, respectively