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ACO1 — EPO
Text-mined interactions from Literome
Bullock et al., Blood 2010
(Anemia, Iron-Deficiency) :
The mechanism for
aconitase regulation of erythropoiesis most probably
involves both production of metabolic intermediates and modulation of
erythropoietin signaling
Weiss et al., Blood 1997
(Leukemia, Erythroblastic, Acute) :
We show that, in human ( K562 ) and murine erythroleukemic cells (MEL),
Epo enhances the binding affinity of iron-regulatory protein
(IRP)-1 , the central regulator of cellular iron metabolism, to specific RNA stem-loop structures, known as iron-responsive elements ( IREs )