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IFNG — MDM2

Text-mined interactions from Literome

MacKenzie et al., Adv Exp Med Biol 1999 : Stimulation of human monocyte-derived-macrophages ( MDM ) with interferon gamma induces the L-tryptophan degrading enzyme indoleamine 2,3-dioxygenase (IDO)
Schlesinger et al., J Immunol 1991 : Paralleling this, IFN-gamma activated MDM exhibit markedly reduced C receptor function, reflected by markedly decreased adherence and ingestion of C3b- and C3bi coated E. Decreased C receptor function by IFN-gamma activated MDM correlates with decreased surface expression of CR1 but not CR3 or CR4 ... This study also demonstrates that IFN-gamma activation markedly reduces the capacity of MDM to phagocytize M. leprae, and it provides a molecular mechanism for this phenomenon decreased C receptor function
Thomas et al., J Biol Chem 2007 : Exposure of IFNgamma stimulated human monocyte derived macrophages ( MDM ) to NO donors had no material impact on IDO mRNA or protein expression, yet exposure of MDM or transfected COS-7 cells expressing active human IDO to NO donors resulted in reversible inhibition of IDO activity
Smith et al., Cytokine 2010 : Further studies to confirm these observations with IFN-gamma activated MDM and other MRSA strains are needed to support clinical trials for difficult-to-treat MRSA infections
Murray et al., Infect Immun 1989 : IFN-gamma readily induced normal monocyte derived macrophages ( MDM ) to express indoleamine 2,3-dioxygenase (IDO) activity and stimulated MDM, alveolar macrophages, and oxidatively deficient chronic granulomatous disease MDM to degrade tryptophan