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EPHB2 — SLC9A1

Text-mined interactions from Literome

Mukhin et al., J Biol Chem 2004 : Inhibition of NHE-1 with pharmacological agents or by isotonic replacement of sodium in the perfusate with choline or tetramethylammonium greatly attenuated ERK activation by 5-HT or Ang II ... Receptor independent activation of NHE-1 by acute acid loading of RASM cells resulted in the rapid phosphorylation of ERK , which could be blocked by pharmacological inhibitors of NHE-1 or by isotonic replacement of sodium, closely linking the proton transport function of NHE-1 to ERK activation
Azriel-Tamir et al., J Biol Chem 2004 : Activation of NHE1 by zinc was totally blocked by the ERK1/2 inhibitor, U0126
Wallert et al., Cell Signal 2005 : The data indicate that ERK activation is essential for phenylephrine stimulation of NHE1 , and that ERK and RhoA are involved in LPA stimulation of NHE1 by more than one mechanism ... These studies indicate a direct involvement of ERK in the alpha ( 1 ) -adrenergic activation of NHE1 and a significant role for both ERK and RhoA in LPA stimulation of NHE1 in CCL39 fibroblasts
Kintner et al., Am J Physiol Cell Physiol 2005 (Calcium Signaling) : Together, our data suggest that ERK1/2 is involved in activation of NHE1 in astrocytes after in vitro ischemia
Cechin et al., Neurochem Res 2005 (Glioma) : Inhibition of Rho kinase or NHE1 did not reduce the LPA induced phosphorylation of ERK , Akt or CREB
Konstantinidis et al., Cell Physiol Biochem 2006 : Additionally, inhibition of NHE1 resulted in ERK inhibition as well
Pedersen et al., Cell Physiol Biochem 2007 (Carcinoma, Ehrlich Tumor) : Here, we show, using a combination of biochemical and molecular biology approaches, that three MAPKs exhibit unique interrelationships with the Na ( + ) /H ( + ) exchanger, NHE1, after osmotic cell shrinkage : Extracellular Signal Regulated Kinase ( ERK1/2 ) is inhibited in an NHE1 dependent, pH(i) independent manner, c-Jun N-terminal kinase (JNK1/2) is stimulated, in part through NHE1 mediated intracellular alkalinization, and p38 MAPK is activated in an NHE1 independent manner, and contributes to NHE1 activation and ERK inhibition ... Shrinkage induced ERK1/2 inhibition was attenuated in Ehrlich Lettre Ascites cells by NHE1 inhibitors ( EIPA, cariporide ) or removal of extracellular Na ( + ), and mimicked by human ( h ) NHE1 expression in cells lacking endogenous NHE1 activity ... The effect of NHE1 on ERK1/2 was pH(i) independent and upstream of MEK1/2
Coccaro et al., Am J Physiol Heart Circ Physiol 2009 (Acidosis...) : We recently demonstrated that extracellular regulated kinase (ERK) mediated activation of NHE1 occurs during ischemia-reperfusion of the myocardium ... The same amino acids were critical to phenylephrine mediated, ERK dependent activation of NHE1 activity and increased the phosphorylation in intact rat cardiomyocytes