Fukukawa et al., Int J Oncol 2005
:
To examine the mode of action by which I-2PP2A/SET suppresses cell proliferation, we determined the effect of over expressed I-2PP2A/SET on ERK activation ... I-2PP2A/SET suppressed activation of ERK following EGF stimulation but did not affect activation levels of stress kinases, JNK and p38 ... By contrast, knocking down I-2PP2A/SET by siRNA resulted in enhancement of ERK and MEK activations, suggesting that I-2PP2A/SET negatively regulates MEK/ERK Bareford et al., Cancer Biol Ther 2012
(Breast Neoplasms...) :
Overexpression of I2PP2A blocked drug induced activation of ERK1/2 and tumor cell killing