Gene interactions and pathways from curated databases and text-mining

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BTK — CSF2

Text-mined interactions from Literome

Schmidt et al., Eur J Immunol 2009 : Finally, a comparison of WT, Tec ( - ) ( / ) ( - ), Btk ( - ) ( / ) ( - ) and Tec ( - ) ( / ) ( - ) Btk ( - ) ( / ) ( - ) BMMC revealed a negative role for Btk in the regulation of IL-4 production, while for the efficient production of TNF-alpha, IL-13 and GM-CSF , both Tec and Btk were required
Fiedler et al., Blood 2011 (Agammaglobulinemia...) : In GMP and neutrophils, Btk plays a role in GM-CSF- and Toll-like receptor induced differentiation
Matsuda et al., Blood 1995 : In this study we show that in addition to Jak family tyrosine kinase, the stimulation of gp130 by IL-6 plus soluble IL-6 receptor alpha induced the activation of Btk and Tec tyrosine kinases, whereas IL-3 and granulocyte colony stimulating factor activated Tec but not Btk in a pro-B cell line