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AKT1 — PPARG

Text-mined interactions from Literome

Goetze et al., Hypertension 2002 : Both PPARgamma-ligands inhibited leptin stimulated Akt and eNOS phosphorylation, but neither attenuated ERK 1/2 activation in response to leptin
Peng et al., Genes Dev 2003 (Abnormalities, Multiple...) : Specifically, Akt1 and Akt2 are required for the induced expression of PPARgamma , the master regulator of adipogenesis, establishing a new essential role for Akt in adipocyte differentiation
Wang et al., Cell Res 2005 : We found that arsenic trioxide induced the expression and the phosphorylation of Akt/PKB and it inhibited the interaction between Akt/PKB and PPARgamma
Lin et al., J Clin Endocrinol Metab 2005 : RSG activation of PPAR-gamma resulted in downstream activation of the serine/threonine protein kinase Akt , an outcome that was inhibited by a specific phosphatidylinositol 3-kinase inhibitor, which ablated RSG protection against h-IAPP induced islet cell apoptosis
Zhou et al., Mol Cell Biochem 2009 : Phosphatidylinositol 3-kinase/AKT ( PI-3 K/AKT ) and extracellular signal regulated kinase ( ERK ) signaling pathways mediate the leptin induced inhibition of PPARgamma gene expression
Kim et al., Biochem Biophys Res Commun 2010 : Here we showed that cAMP induced activation of protein kinase A (PKA) and Akt is essential for the transcriptional activation of PPAR-gamma ... In addition, IBMX induced PPAR-gamma transcriptional activity was blocked by PI3K/Akt , PKA, or Rap1 inhibitors ... These results indicate that both PKA and Akt signaling pathways are required for transcriptional activation of PPAR-gamma , suggesting post-translational activation of PPAR-gamma might be critical step for adipogenic gene expression