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Molecular pharmacology and antitumor activity of PHT-427, a novel Akt/phosphatidylinositide dependent protein kinase 1 pleckstrin homology domain inhibitor
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Binding of phosphoinositide 3-OH kinase products to the pleckstrin homology domain results in translocation of PKB/Akt to the plasma membrane where it is activated by phosphorylation by upstream kinases including the phosphoinoside dependent kinase 1 (PDK1) ... Binding of phosphoinositide 3-OH kinase products to the pleckstrin homology domain results in translocation of PKB/Akt to the plasma membrane where it is activated by phosphorylation by upstream kinases including the phosphoinoside dependent kinase 1 (PDK1)