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AKT1 — CA2
Text-mined interactions from Literome
Takahashi et al., Am J Physiol 1999
:
Akt/PKB activity was stimulated by the Ca2+ ionophore ionomycin, suggesting the possible
involvement of
Ca2+ in ANG II-stimulated
Akt/PKB activation
Egea et al., J Cell Biol 2001
:
In this report, we have analyzed the
involvement of
Ca2+ and calmodulin (CaM) in the activation of the
PKB induced by NTs
Tang et al., J Biol Chem 2002
(Astrocytoma...) :
Muscarinic receptors mediate phospholipase C-dependent
activation of
protein kinase B via
Ca2+ , ErbB3, and phosphoinositide 3-kinase in 1321N1 astrocytoma cells
Spicer et al., Endocr Pathol 2003
:
Research over the last few years has revealed that the hypoxia response in PC12 cells involves the interactions of several signal transduction pathways (
Ca2+/calmodulin dependent kinases,
Akt , SAPKs, and MAPKs ) and transcription factors ( HIFs, CREB, and c-fos/junB )
Crossthwaite et al., J Neurochem 2004
:
We have previously shown that
Ca2+-influx through NMDA receptors in cultured striatal neurones
mediates the phosphorylation of extracellular signal regulated kinase 1/2 ( ERK1/2 ) and
Akt/protein kinase B (PKB) through a phosphatidylinositol 3-kinase ( PI 3-kinase ) -dependent pathway
Ozeki et al., Mol Cell Biochem 2004
(Calcium Signaling) :
However, it is not known if activation of
Akt is itself
involved in the regulation of
Ca2+ signals produced in these cells ... The objective of this study was to examine if
Akt is
involved in the regulation of
Ca2+ signaling in endothelial cells ... Agonist stimulated
Ca2+ signals, assessed using fura-2, were compared in porcine aortic endothelial cells under control conditions or conditions in which Akt was
blocked either by different inhibitors of phosphatidylinositol 3-kinase ( PI3 kinase ) /Akt or by transient expression of a dominant negative form of
Akt ( dnAkt ) ... We conclude that
Akt is not
involved in the regulation of agonist stimulated
Ca2+ signals in endothelial cells
Yasuoka et al., J Biol Chem 2004
:
Antiapoptotic activity of
Akt is
down-regulated by
Ca2+ in myocardiac H9c2 cells
Evans et al., J Biol Chem 2006
:
Secretory stimuli in both intact and permeabilized cells induced Akt phosphorylation on serine 473, and the time course of
Ca2+ induced
Akt phosphorylation was similar to that of exocytosis in permeabilized cells
Yamaguchi et al., J Am Soc Nephrol 2006
(Polycystic Kidney Diseases...) :
Elevation of intracellular
Ca2+ levels in ADPKD cells
increased Akt activity and blocked cAMP dependent B-Raf and ERK activation
Catalucci et al., J Cell Biol 2009
(Calcium Signaling...) :
Akt regulates L-type
Ca2+ channel activity by modulating Cavalpha1 protein stability