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MIR21 — PTEN

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: PTEN → MIR21 (directlyDecreases)
  Evidence: miR-21 was noted to be highly overexpressed in HCC tumors and cell lines in expression profiling studies using a miRNA microarray. Inhibition of miR-21 in cultured HCC cells increased expression of the phosphatase and tensin homolog (PTEN) tumor suppressor, and decreased tumor cell proliferation, migration, and invasion. In contrast-enhanced miR-21 expression by transfection with precursor miR-21 increased tumor cell proliferation, migration, and invasion. PTEN was shown to be a direct target of...

Text-mined interactions from Literome

Wang et al., Arch Med Res 2011 (Breast Neoplasms) : MiR-21 inhibitor could increase PTEN protein expression and the luciferase activity of a PTEN 3 ' untranslated region based reporter construct in MCF-7/ADR cells
Liu et al., Chin Med Sci J 2012 (Bile Duct Neoplasms...) : The dual luciferase reporter gene assay revealed endogenous microRNA-21 in cholangiocarcinoma cell line, QBC939, inhibited the luciferase reporter activities of wild-type PTEN ( P < 0.01 ) and PDCD4 ( P < 0.05 ) and had no this effect on mutated PTEN and PDCD4