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IGFBP1 — IL6
Text-mined interactions from Literome
Feliers et al., Br J Haematol 1999
(Multiple Myeloma) :
In contrast,
IGFBP4 was not regulated in
response to
IL-6 , TNF-alpha, PDGF BB, bFGF, TGF-beta or the cAMP agonist, forskolin
Lelbach et al., J Hepatol 2001
:
In cocultures, biosynthesis of
IGFBP-1 , -3 and -4 was
increased dose-dependently by
IL-6 , while the effects of IL-1beta or TNFalpha were less prominent
Pihl et al., Horm Res 2006
:
Acute
interleukin-6 infusion
increases IGFBP-1 but has no short-term effect on IGFBP-3 proteolysis in healthy men ... These data suggest that moderately elevated levels of
IL-6 such as in the post-operative state or after exercise may
contribute to increased levels of
IGFBP-1
Wang et al., Atherosclerosis 2012
(Carotid Artery Diseases) :
In vitro studies showed that IL-1ß,
IL-6 and TNFa
stimulated IGFBP-1 mRNA expression in SMCs. IGFBP-1 stimulated SMC proliferation through ERK1/2 activation but independently of the IGF-1 receptor