Zhang et al., J Biol Chem 2005
(Breast Neoplasms...) :
E6 and E7 also antagonized the ability of BRCA1 to inhibit c-Myc E-box mediated transactivation and human telomerase reverse transcriptase promoter activity, in a manner dependent upon the zinc finger domains
Ballal et al., J Biol Chem 2009
:
We now report that BRCA1 knockdown causes increased telomerase reverse transcriptase expression, telomerase activity, and telomere length ; but studies utilizing a combination of BRCA1 and telomerase reverse transcriptase small interfering RNAs suggest that BRCA1 also regulates telomere length independently of telomerase