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DUSP1 — PTGS2

Text-mined interactions from Literome

Turpeinen et al., J Pharmacol Exp Ther 2010 : In the present study, we investigated the effect of MKP-1 on the expression of interleukin (IL)-6, IL-8 and cyclooxygenase (COX)-2 in response to stimulation with cytokines ( tumor necrosis factor, IL-1beta, and interferon-gamma ; 10 ng/ml each ) in A549 human lung epithelial cells ... Down-regulation of MKP-1 with small interfering RNA enhanced p38 and JNK phosphorylation and increased IL-6, IL-8, and COX-2 expression in A549 cells
Tomaru et al., Toxicol Mech Methods 2011 : Although a marked induction of MAPK phosphatase (MKP)-1 expression was observed in A549 cells exposed to crystalline silica, the silencing of MKP-1 expression using short interference RNA did not affect silica induced COX-2 expression, suggesting that the down-regulation of COX-2 expression by MKP-1 is unlikely
Hsu et al., Biochim Biophys Acta 2011 : TSA suppression of JNK and p38MAPK phosphorylation and subsequent COX-2 expression were restored by selective inhibition of MKP-1 using MKP-1 siRNA