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P2RY2 — VCAM1

Text-mined interactions from Literome

Seye et al., J Biol Chem 2003 : The P2Y2 nucleotide receptor mediates UTP induced vascular cell adhesion molecule-1 expression in coronary artery endothelial cells ... Results indicated that the equipotent P2Y2 receptor agonists UTP or ATP ( 1-100 microm ) stimulated the expression of vascular cell adhesion molecule-1 ( VCAM-1 ) in human coronary artery endothelial cells ( HCAEC ) in a time- and dose dependent manner ... These findings suggest a novel role for the P2Y2 receptor in the p38- and Rho kinase dependent expression of VCAM-1 that mediates the recruitment of monocytes by vascular endothelium associated with the development of atherosclerosis
Seye et al., J Biol Chem 2004 (Arteriosclerosis) : The P2Y2 nucleotide receptor mediates vascular cell adhesion molecule-1 expression through interaction with VEGF receptor-2 ( KDR/Flk-1 ) ... RNA interference targeting VEGFR-2 or inhibition of VEGFR-2 tyrosine kinase activity abolishes P2Y(2)R mediated VCAM-1 expression ... Significantly, a dominant negative form of RhoA inhibited P2Y(2)R mediated VCAM-1 expression, whereas expression of dominant negative forms of Cdc42 and Rac1 had no effect
Baker et al., Mol Immunol 2008 : Furthermore, P2Y2R activation mediated the up-regulation of VCAM-1 expression in HSG cells leading to increased adherence of lymphocytic cells ... Inhibitors of EGFR phosphorylation and metalloprotease activity abolished P2Y2R mediated VCAM-1 expression and decreased lymphocyte binding to HSG cells ... These results suggest that P2Y2R activation in salivary gland cells increases the EGFR dependent expression of VCAM-1 and the binding of lymphocytes, a pathway relevant to inflammation associated with SS